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Npgrj_nsmb_950 608..614
The enzymatic transfer of activated mannose yields mannosides in glycoconjugates and oligoand polysaccharides. Yet, despite its biological necessity, the mechanism by which glycosyltransferases recognize mannose and catalyze its transfer to acceptor molecules is poorly understood. Here, we report broad high-throughput screening and kinetic analyses of both natural and synthetic substrates of Rh...
متن کاملDmd049239 608..614
The purpose of this study was to quantitatively determine the contribution of PepT1 [peptide transporter 1 (SLC15A1)] to the intestinal permeability of valacyclovir, an ester prodrug of the antiviral drug acyclovir. In situ single-pass intestinal perfusions were employed (pH 6.5 3 90 minutes) to assess the effective permeability (Peff) of 100 mM [ H]valacyclovir in wild-type and PepT1 knockout ...
متن کاملMAT 614 Notes on Infinitesimal Deformation Theory
For every local ring R in what follows, mR denotes the maximal ideal. Let Λ̃ be a complete, regular, local Noetherian ring, let E ⊂ m Λ̃ be an ideal, and denote the quotient by Λ. Thus, Λ is also a complete, local Noetherian ring. Denote the residue field Λ/mΛ by k. Denote by C = CΛ the category whose objects are Λ-algebras A such that (i) A is a local, Artin ring with mΛA ⊂ mA, and (ii) the indu...
متن کاملMAT 614 Curves on Algebraic Varieties
(f) Explicitly verify that the the 5 global sections above generate the invertible sheaf OP2(2)|X(−C) at every point of X. Therefore there is a unique morphism φ : X → P such that φOP4(1) equals OP2(2)|X(−C) and the pullback of the homogeneous coordinates are the 5 sections above. (g) Also verify that y0, y1, y2, y3 are identically zero on the line L. Therefore φ contracts L to the point p = [0...
متن کاملLecture Notes Eco 613/614 Fall 2007
This infinite-dimensional object is a function of the current state. We have to decide how to approximate it numerically. One approach is to discretize the state and approximate the conditional expectation by the finite set of its values at each point in the state space. This technique involves replacing the continuous-valued Markov chain for λ with a finitely-many-discrete-valued Markov chain....
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ژورنال
عنوان ژورنال: Pediatric Critical Care Medicine
سال: 2018
ISSN: 1529-7535
DOI: 10.1097/01.pcc.0000538071.66965.11